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Non-Nutritive Sweetener Consumption and Glucose Homeostasis in Older Adults With Prediabetes
Sponsor: Virginia Polytechnic Institute and State University
Summary
Animal and observational research in humans suggest that specific types of non-nutritive sweeteners (NNS) may impair glycemic control. However, whether NNS consumption impacts glucose homeostasis in middle-aged/older adults with prediabetes is unknown, and potential mechanisms by which this could occur have yet to be identified. The overall objective of this R21 proposal is to establish proof-of-concept for alterations in glucose homeostasis following intake of sucralose, but not aspartame, in middle-aged/older adults with prediabetes compared to a eucaloric diet with no NNS.
Official title: Non-Nutritive Sweetener Consumption (Aspartame and Sucralose) and Glucose Homeostasis in Older Adults With Prediabetes
Key Details
Gender
All
Age Range
40 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2023-04-18
Completion Date
2026-02-28
Last Updated
2025-12-04
Healthy Volunteers
No
Conditions
Interventions
Non-Nutritive Sweetener Intake and impact on glucose homeostasis
Provision of either aspartame, sucralose, or control with no non-nutritive sweeteners to a controlled feeding study to determine impacts on glucose homeostasis.
Locations (1)
Virginia Tech
Blacksburg, Virginia, United States