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A Study of Nivolumab and Relatlimab in Combination With Bevacizumab in Advanced Liver Cancer
Sponsor: Bristol-Myers Squibb
Summary
The purpose of this study is to evaluate the safety and effectiveness of triplet therapy of nivolumab, relatlimab and bevacizumab versus nivolumab and bevacizumab in participants with untreated advanced/metastatic hepatocellular carcinoma (HCC).
Official title: A Phase 1/2, Safety Confirmation, Placebo-controlled, Randomized Study of Nivolumab in Combination With Relatlimab and Bevacizumab in Treatment-naive Advanced/Metastatic Hepatocellular Carcinoma
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
82
Start Date
2022-05-05
Completion Date
2025-11-18
Last Updated
2026-10-14
Healthy Volunteers
No
Conditions
Interventions
Relatlimab
Specified dose on specified days
Nivolumab
Specified dose on specified days
Bevacizumab
Specified dose on specified days
Placebo
Specified dose on specified days
Locations (61)
Local Institution - 0042
Los Angeles, California, United States
Local Institution - 0039
Los Angeles, California, United States
Local Institution - 0034
San Francisco, California, United States
Local Institution - 0030
Washington D.C., District of Columbia, United States
Local Institution - 0059
Baltimore, Maryland, United States
Local Institution - 0060
Boston, Massachusetts, United States
Local Institution - 0065
Boston, Massachusetts, United States
Local Institution - 0061
New York, New York, United States
Local Institution - 0062
The Bronx, New York, United States
Local Institution - 0033
Milwaukee, Wisconsin, United States
Local Institution - 0045
Camperdown, New South Wales, Australia
Local Institution - 0022
Adelaide, South Australia, Australia
Local Institution - 0026
Heidelberg, Victoria, Australia
Local Institution - 0013
Melbourne, Victoria, Australia
Local Institution - 0017
Nedlands, Western Australia, Australia
Local Institution - 0025
Edmonton, Alberta, Canada
Local Institution - 0009
Toronto, Ontario, Canada
Local Institution - 0064
Guangzhou, Guangdong, China
Local Institution - 0066
Xi'an, Shan3xi, China
Local Institution - 0021
Avignon, Cedex 9, France
Local Institution - 0012
Grenoble, France
Local Institution - 0001
Nice, France
Local Institution - 0002
Reims, France
Local Institution - 0008
Rennes, France
Local Institution - 0054
Suresnes, France
Local Institution - 0051
Düsseldorf, North Rhine-Westphalia, Germany
Local Institution - 0035
Frankfurt, Germany
Local Institution - 0057
Mainz, Germany
Local Institution - 0055
Munich, Germany
Local Institution - 0004
Hong Kong, Hong Kong
Local Institution - 0031
Shatin, Hong Kong
Local Institution - 0036
Milan, Italy
Local Institution - 0003
Padova, Italy
Local Institution - 0010
Roma, Italy
Local Institution - 0047
Kashiwa-shi, Chiba, Japan
Local Institution - 0048
Matsuyama, Ehime, Japan
Local Institution - 0058
Kanazawa, Ishikawa-ken, Japan
Local Institution - 0050
Yokohama, Kanagawa, Japan
Local Institution - 0041
Sayama, Osaka, Japan
Local Institution - 0063
Chuo-ku, Tokyo, Japan
Local Institution - 0028
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland
Local Institution - 0016
Warsaw, Masovian Voivodeship, Poland
Local Institution - 0023
Gdansk, Poland
Local Institution - 0052
Rio Piedras, PR, Puerto Rico
Local Institution - 0019
San Juan, Puerto Rico
Local Institution - 0029
Singapore, Singapore
Local Institution - 0027
Singapore, Singapore
Local Institution - 0018
Singapore, Singapore
Local Institution - 0044
Singapore, Singapore
Local Institution - 0037
Seongnam-si, Gyeonggido, South Korea
Local Institution - 0056
Seoul, South Korea
Local Institution - 0032
Santiago de Compostela, A Coruña, Spain
Local Institution - 0007
Santander, Cantabria, Spain
Local Institution - 0067
Madrid, Sede Madrid, Spain
Local Institution - 0053
Madrid, Spain
Local Institution - 0038
Pamplona, Spain
Local Institution - 0040
Zaragoza, Spain
Local Institution - 0043
District Taichung City, Tai Zhong Shi, Taiwan
Local Institution - 0024
Taichung, Taiwan
Local Institution - 0046
Taipei, Taiwan
Local Institution - 0049
Taipei, Taiwan