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Improving Neurotrauma by Depolarization Inhibition With Combination Therapy (INDICT)
Sponsor: University of Cincinnati
Summary
This study is a randomized Phase 2 trial to determine the feasibility of real-time electrocorticographic monitoring of spreading depolarizations (SD) to guide implementation of a tier-based protocol of intensive care therapies, aimed at SD suppression, for the management of patients who have undergone acute operative treatment of severe traumatic brain injury.
Official title: Improving Neurotrauma by Depolarization Inhibition With Combination Therapy (INDICT): a Phase 2 Randomized, Feasibility Trial
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
72
Start Date
2022-12-16
Completion Date
2027-03-20
Last Updated
2025-12-22
Healthy Volunteers
No
Conditions
Interventions
Full-band Electrocorticography
Diagnosis of spreading depolarizations in continuous electrocorticography
Treatment Algorithm
Protocol for escalation and de-escalation of physiologic-targeted and pharmacologic therapies to treat and prevent spreading depolarizations
Locations (1)
University of Cincinnati
Cincinnati, Ohio, United States