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Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy
Sponsor: University Hospital Freiburg
Summary
The number of elderly head-and-neck squamous cell carcinoma (HNSCC) patients is increasing; however, the evidence regarding the ideal treatment for this often vulnerable and frail patient cohort is limited. Although the benefit of concomitant chemotherapy has been reported to decrease in elderly HNSCC patients based on the MACH-NC meta-analysis, it remains unknown whether state-of-the art radiotherapy techniques such as intensity-modulated radiotherapy (IMRT), modern supportive treatments and alternative chemotherapy fractionation (e.g., cisplatin weekly) may have altered this observation. The objective of this retrospective multinational multicenter study is to determine the oncological outcomes of elderly patients (≥65 years) with locally advanced HNSCCs undergoing definitive (chemo-)radiation and to investigate the influence of concomitant chemotherapy on overall survival and progression-free survival after adjusting for potential confounder variables such as age, performance status and comorbidity burden.
Key Details
Gender
All
Age Range
65 Years - Any
Study Type
OBSERVATIONAL
Enrollment
1500
Start Date
2021-06-01
Completion Date
2026-12-31
Last Updated
2025-03-25
Healthy Volunteers
No
Locations (18)
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine
Baltimore, Maryland, United States
Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai
New York, New York, United States
Department of Radiation Oncology, Case Western Reserve University
Cleveland, Ohio, United States
Division of Radiation Oncology, The Ohio State University Wexner
Columbus, Ohio, United States
Radiation Oncology Department, German Oncology Center
Limassol, Cyprus
Brno University Hospital
Brno, Czechia
Department of Radiooncology and Radiotherapy, Charité-Universitätsmedizin Berlin
Berlin, Germany
Department of Radiation Oncology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg
Erlangen, Germany
Department of Radiotherapy and Oncology, Goethe-University Frankfurt am Main
Frankfurt, Germany
University of Giessen
Giessen, Germany
Martin-Luther-Universität Halle-Wittenberg
Halle, Germany
Jena University Hospital
Jena, Germany
Department of Radiation Oncology, University Hospital Schleswig-Holstein
Kiel, Germany
Department of Radiation Oncology, University Medical Center Leipzig
Leipzig, Germany
Department of Radiation Oncology, University Medical Center Mainz
Mainz, Germany
Department of Radiation Oncology, University Hospital, LMU Munich
Munich, Germany
Department of Radiation Oncology, University Hospital Würzburg
Würzburg, Germany
Department of Radiation Oncology, University Hospital Zurich (USZ), University of Zurich (UZH)
Zurich, Switzerland