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Protective Effect of Thymosin Α1 Against Negative Immune Dysregulation and Organ Dysfunction After Acute Aortic Dissection Surgery (PANDA II)
Sponsor: Nanjing Medical University
Summary
Systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) are the major causes of death in patients with acute aortic syndrome (AAS). Therefore, the prevention of SIRS and MODS is of great clinical value, and immunomodulatory therapy with thymosin alpha 1 may be beneficial. This study was designed to test the hypothesis that the administration of thymosin alpha 1 during the acute phase of AAS will result in a reduced incidence of SIRS and MODS.
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
330
Start Date
2022-07-01
Completion Date
2025-12-31
Last Updated
2024-12-12
Healthy Volunteers
No
Interventions
Thymosin Alpha1, 28A-Glycine-28B-L-Arginine-28C-L-Glutamic Acid-28D-L-Alanine-28E-L-Proline-28F-L-Alanine-28G-L-Asparagine-
Thymosin alpha 1, 1.6mg injection hypodermic (I.H), every 12 hours for 5 days at least during the ICU admission. The administration will be terminated any day during the treatment when the patient is deemed as qualified for ICU discharge or dead.
Blank control
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Locations (15)
The First Affiliated Hospital of Bengbu Medical College
Bengbu, Anhui, China
Guangdong Provincial People's Hospital
Guangzhou, Guangdong, China
The First Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China
Nanjing First Hospital Nanjing Medical University
Nanjing, Jiangsu, China
Subei People's Hospital of Jiangsu Province
Yangzhou, Jiangsu, China
Qilu Hospital of Shandong University
Jinan, Shandong, China
West China Hospital of Sichuan University
Chengdu, Sichuan, China
The Friendship Hospital of Yili Kazak Autonomous Prefecture
Kazak, Xinjiang, China
The Seventh Affiliated Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, China
The First Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, China
Beijing Anzhen Hospital Capital Medical University
Beijing, China
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, China
The Second Affiliated Hospital of Nanchang University
Nanchang, China
Shanghai East Hospital Tongji University
Shanghai, China
TEDA International Cardiovascular Hospital
Tianjin, China