Clinical Research Directory

Inclusion Criteria: 1. Age between 18 and 75; 2. Signed the informed consent form； 3. Subjects in the ND group are the healthy participants without diabetes； 4. Subjects in the NWD group are the diabetic participants without newly identified wounds； 5. Subjects in the CWD group are the diabetic participants with chronic wounds Exclusion Criteria: 1. With sever acute underlying diseases of the brain, heart, lungs, liver and/or kidney; 2. No diabetes but combined with lower limb arterial stenosis, occlusion or other conditions affecting wound healing or other causes of wounds such as varicose veins in the lower limbs; 3. Special exclusion criteria for blood, urine and stool samples taking.