Clinical Research Directory

Inclusion Criteria: * Males and females between the ages of 11-14 years * Parent or full biological sibling with major depressive disorder and/or bipolar I/II disorder * Elevated mood lability, which is defined as \>10 on the Children's Affective Lability Scale (averaging the child and parent score). Exclusion Criteria: * IQ\<70 or significant learning disability (which will make it difficult to participate in study procedures) * Current or previous diagnosis of bipolar disorder, schizophrenia, schizoaffective disorder, or autism spectrum disorder * Current diagnosis of major depressive disorder * Contraindications to scanning, including metal in the body (e.g. has braces or planning to get braces within the next 8 months) * Suicidal or homicidal ideation within the past month * Changed medications or medication doses (including psychotropic medications and/or hormonal contraceptives), or have started a new therapy, within the past two months. For each eligible youth, a parent (when possible, the parent with a mood disorder) will also be enrolled in the study, to provide a detailed account of family history. The only inclusion criterion for the parent participants is that they have an eligible child.