Clinical Research Directory

Inclusion Criteria: * Males with sexual hormone deficiency aged 50 to 70 years * AMS score ≥ 27 * IIEF \< 14 * SQoL-M ≤ 87 * and Testosterone ≤ 12 nMol/L * Normal liver function (ALT, AST and Bilirubin are normal according to biological index of Vietnamese people). * Normal kidney function is usually according to the biological index of Vietnamese people. * No infection, HIV, HBV, active syphilis. * Must provide written informed consent. Exclusion Criteria: * The patient had surgery to remove the gonads. * Patients with a history of cancer, or undergoing cancer treatment, or are positive for cancer screening tests including: PSA, AFP, Pepsinogen I, Pepsinogen II and erythrocyte smear test. The patient is taking anti-rejection drugs. * Patients with malformations, malformations or tumors of the endocrine glands. * Endocrine impairment due to diabetes (HBA1c \> 7) and other metabolic diseases. * Patients with active autoimmune disease or positive for antinuclear antibodies. * Patients with severe heart failure, severe renal failure, severe liver failure, severe respiratory failure, history of cerebral infarction, myocardial infarction, Alzeimer. * Patients with hypothyroidism. * The patient has an acute infection. * Patients with clinically significant coagulopathy or other hematological diseases. * History of allergy to anesthetics, anesthetics, antibiotics. * Patients who are using other hormone-improving drugs or supplements (including Sildenafil) in the last 2 weeks or want to continue using these drugs during the study period. * The patient is a smoker.