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RECRUITING
NCT05345613
PHASE4

Tranexamic Acid During Colonic Endoscopic Resection Procedures

Sponsor: Assaf-Harofeh Medical Center

View on ClinicalTrials.gov

Summary

Colonoscopy with polypectomy reduces the incidence and mortality associated with colon cancer. However, polypectomy is associated with adverse events such as bleeding. Tranexamic acid (TXA) is a synthetic derivative of lysine that exerts antifibrinolytic effects and may prevent bleeding. The investigators aim to evaluate the effect of local TXA on preventing intraprocedural and postprocedural bleeding in patients undergoing endoscopic mucosal resection (EMR) of large colon polyps.

Official title: Usage of Tranexamic Acid During Colonic Endoscopic Resection Procedures for Reduction Intraprocedural and Postprocedural Bleeding

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

200

Start Date

2022-05-01

Completion Date

2026-10-01

Last Updated

2026-01-13

Healthy Volunteers

No

Conditions

Interventions

DRUG

Tranexamic acid

Submucosal injection of standard solution including TXA during EMR procedure

DRUG

Standard

Injection of standard solution

Locations (1)

Shamir Medical Center

Be’er Ya‘aqov, Israel