Clinical Research Directory

Inclusion Criteria: * Age 18 - 60 * For women, premenopausal status Exclusion Criteria: * Active cardiovascular or pulmonary disease (e.g. hypertension, coronary artery disease, cardiomyopathy, arrhythmia, valvular abnormalities, diabetes, peripheral vascular disease, tobacco use, chronic obstructive pulmonary disease, asthma, interstitial lung disease, restrictive lung disease, or pulmonary hypertension) * Use of cardiac- or pulmonary-related medications * Prior history of high altitude pulmonary edema or high altitude cerebral edema * Body mass index \< 18.5 or \> 30 * Anemia * Iron deficiency * Iron supplementation (oral or intravenous) in the preceding 60 days * Systemic anticoagulation or aspirin use that cannot be temporarily held for the study * Pregnancy * Non-cardiopulmonary disorders that adversely influence exercise ability (e.g. arthritis or peripheral vascular disease) * Dedicated athletic training (defined here as spending \>9 hours per week in vigorous physical activity \[≥6 mets\]) * Regular high-altitude exercise (defined here as engaging in vigorous physical activity \[≥1 hour at ≥6 mets\] at ≥8,000 ft for \>2 days per week over the preceding 4 weeks) * Residence at ≥8,000 ft for 3 or more consecutive nights in the preceding 30 days