Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Adults With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease (Established or at Increased Risk for), and/or With Severe Hypertriglyceridemia
Sponsor: Ionis Pharmaceuticals, Inc.
Summary
The purpose of the study was to evaluate the effect of olezarsen on percent change in fasting triglyceride (TG) levels compared to placebo at Months 6 and 12 and the proportion of participants who achieve different thresholds in fasting TG. Other objectives were to evaluate the effect of olezarsen on percent change in fasting apolipoprotein C-III (apoC-III), very low-density lipoprotein cholesterol (VLDL-C), remnant cholesterol, non-high-density lipoprotein cholesterol (non-HDL-C), HDL-C, total cholesterol (TC), apolipoprotein B (apoB), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein A-1 (apoA-1).
Official title: A Randomized, Double-blind, Placebo-Controlled, Phase 2b Study of ISIS 678354 in Patients With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease (Established or at Increased Risk for), and/or With Severe Hypertriglyceridemia
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
154
Start Date
2022-05-09
Completion Date
2023-12-21
Last Updated
2026-04-23
Healthy Volunteers
No
Interventions
Olezarsen
SC injection.
Placebo
SC injection.
Locations (24)
Clinical Trials Research
Lincoln, California, United States
Catalina Research Institute, LLC
Montclair, California, United States
Excel Medical Clinical Trials, LLC
Boca Raton, Florida, United States
De La Cruz Research Center
Miami, Florida, United States
Suncoast Clinical Research, Inc.
New Port Richey, Florida, United States
Research Physicians Network Alliance
Winter Park, Florida, United States
IACT Health
Columbus, Georgia, United States
Evanston Premier Healthcare Research
Evanston, Illinois, United States
Clinical Investigation Specialist
Gurnee, Illinois, United States
West Broadway Clinic
Council Bluffs, Iowa, United States
Louisville Metabolic and Atherosclerosis Research Center (L-MARC)
Louisville, Kentucky, United States
Aa Mrc, Llc
Flint, Michigan, United States
Clinical Research of South Nevada
Las Vegas, Nevada, United States
Palm Research Center, Inc.
Las Vegas, Nevada, United States
Green and Seidner Family Practice Associates
Lansdale, Pennsylvania, United States
Main Street Physicians Care Waterway
Little River, South Carolina, United States
Health Concepts
Rapid City, South Dakota, United States
Tennessee Center for Clinical Trials
Tullahoma, Tennessee, United States
Southern Endocrinology Associates
Mesquite, Texas, United States
Manassas Clinical Research Center
Manassas, Virginia, United States
York Clinical Research LLC
Norfolk, Virginia, United States
Bluewater Clinical Research Group Inc
Sarnia, Ontario, Canada
Ecogene-21
Chicoutimi, Quebec, Canada
Clinique des Maladies Lipidiques de Quebec Inc.
Québec, Canada