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Recording of Intraoperative Spinal Cord Stimulation and Monitoring
Sponsor: University of California, Los Angeles
Summary
Opioid overdose suppresses brainstem respiratory circuits, causes apnea, and may result in death. Epidural electrical stimulation (EES) at the cervical spinal cord facilitated motor activity in rodents and humans, and we hypothesized that EES of the cervical spinal cord could antagonize opioid-induced respiratory depression in humans. In this study, we will stimulate the spinal cord during surgery and assess its effects on respiratory function in human patients.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2011-01-21
Completion Date
2027-01-22
Last Updated
2025-03-10
Healthy Volunteers
No
Interventions
epidural electrical stimulation
Electrical spinal cord stimulation will be used to modulate respiratory function during general anesthesia.
Locations (1)
University of California, Los Angeles
Los Angeles, California, United States