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Clinical Characteristics of People With Long-term Type 1 Diabetes
Sponsor: Second Xiangya Hospital of Central South University
Summary
Type 1 diabetes (T1D) is characterized by absolute insulin deficiency. Although the discovery and application of exogenous insulin has prolonged the lifespan of T1D patients, the chronic diabetic complications caused by long-term poor glycemic control will still reduce patients' quality of life and the overall life expectancy. According to the studies focused on long-term T1D, part of the patients with long disease duration showed resistance to microvascular complications, and several protective factors have been identified. The prevalence of T1D in China is extremely low compared to that in the western world, and little is known about the characteristics of patients with long-term T1D in China. Therefore, this study is designed to collect variable clinical and laboratory features of patients with long-term T1D, explore the risk and protective factors for the development of microvascular complications, and provide reference for the prediction and prevention of these complications.
Official title: Clinical Characteristics of People With Long-term Type 1 Diabetes: a Cohort Study
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
400
Start Date
2022-05-01
Completion Date
2027-12-31
Last Updated
2022-05-04
Healthy Volunteers
No
Conditions
Interventions
Chronic hyperglycemia
For each follow-up, the glycated albumin(GA) reflecting glycemic control of the past 2-3 weeks, the glycated hemoglobin(HbA1c) reflecting glycemic control of the past 2-3 months, and the advanced glycation end products(AGEs) will be measured.
Residual islet function
For each follow-up, fasting and stimulated C-peptide levels will be measured.
Genetic variation
Genetic variations of interest will be detected with the blood sample collected at baseline.
Dietary constitutes
For each follow-up, the dietary constitutes for the past 3 days will be recorded.
Microbiome composition and function
For each follow-up, the fecal and oral samples will be collected for measurement.
Metabolome composition
For each follow-up, the serum and urine samples will be collected for measurement.
Composition of peripheral blood immune cells
For each follow-up, the peripheral blood mononuclear cells will be collected for measurement.
Locations (1)
Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University
Changsha, Hunan, China