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A First Step Towards Ultra-hypofractionation for Unfavourable Intermediate and High-risk Prostate Cancer
Sponsor: Erasmus Medical Center
Summary
This study aims to make a first step towards ultra-hypofractionation for high-risk prostate cancer by proving the technical feasibility of margin reduction of the seminal vesicles by combining the intra-fraction fiducial tracking with an online re-planning workflow for each fraction to account for the inter-fraction seminal vesicle motion.
Official title: A First Step Towards Ultra-hypofractionation for Unfavourable Intermediate and High-risk Prostate Cancer: a Prospective Safety and Feasibility Study in Patients With Metastatic Prostate Cancer
Key Details
Gender
MALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
35
Start Date
2022-07-07
Completion Date
2027-02
Last Updated
2024-08-28
Healthy Volunteers
No
Conditions
Interventions
Adaptive radiotherapy according to UPRATE protocol
According to previously reported STAMPEDE trial (Parker et al.), patients will be treated with 6 weekly fractions of 6 Gy. According to local protocol the target will consist of prostate and entire seminal vesicles. Additional CT-scans will be made prior to and directly following each fraction. For more details, see study description
Locations (1)
Erasmus Medical Centre
Rotterdam, South Holland, Netherlands