Clinical Research Directory

Inclusion Criteria: * NF1 diagnosis based on NIH Consensus Conference Criteria and/or genetic testing * Measurable cutaneous neurofibromas (cNFs) with or without plexiform NF * Aged 18 years or older at the time of written consent * Voluntary signed written consent obtained before the performance of any study-related procedure not part of normal medical care Exclusion Criteria: * Concurrent treatment with selumetinib or other MAPK, MEK or mTOR inhibitors, other targeted therapies, chemotherapy or radiation * Conditions requiring systemic immunosuppression * Swallowing difficulties or strong gag reflex which may interfere with study compliance * Any comorbidities that may affect study participation in the judgement of enrolling investigator * Psychiatric illness, cognitive challenges, social situations, or other circumstances that would limit compliance with study requirements, per judgment of the enrolling investigator * Treatment with high phenolic olive oil or curcumin within six months of study entry * Known pregnancy or anticipated conception during the 1 year study period