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ACTIVE NOT RECRUITING
NCT05364008
PHASE3

FRIEND: Fibroids and Unexplained Infertility Treatment With Epigallocatechin Gallate; A Natural CompounD in Green Tea

Sponsor: Yale University

View on ClinicalTrials.gov

Summary

The objective of this study is to determine the effect of low caffeine green tea extract containing 45% epigallocatechin gallate (EGCG) on fibroids and subsequent pregnancy and live births in women seeking fertility treatment. The population will consist of 50 women desirous of conceiving, ages ≥18 to ≤40 years (at time of consent), and known to have class 2-6 fibroids, according to the FIGO staging system.

Official title: Fibroids and Unexplained Infertility Treatment With Epigallocatechin Gallate; A Natural CompounD in Green Tea (FRIEND)

Key Details

Gender

FEMALE

Age Range

18 Years - 40 Years

Study Type

INTERVENTIONAL

Enrollment

33

Start Date

2023-01-05

Completion Date

2026-09-30

Last Updated

2026-03-23

Healthy Volunteers

No

Interventions

DRUG

Green Tea Extract

Green tea extract 1650 mg/day (45% EGCG) along with ovarian stimulation with clomiphene citrate and timed intrauterine insemination for up to 4 cycles.

OTHER

Placebo

Placebo 1650 mg/day along with ovarian stimulation with clomiphene citrate and timed intrauterine insemination for up to 4 cycles.

Locations (4)

Yale School of Medicine Dept.of Ob/Gyn & Reproductive Sciences

New Haven, Connecticut, United States

University of Illinois at Chicago College of Medicine

Chicago, Illinois, United States

University of Chicago, Department of Obstetrics and Gynecology

Chicago, Illinois, United States

Johns Hopkins, Division of Reproductive Science and Women's Health Research

Baltimore, Maryland, United States