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Renal Metabolism in Salt-sensitive Human Blood Pressure
Sponsor: Medical College of Wisconsin
Summary
Salt sensitive hypertension is a significant health problem worldwide and a primary modifiable risk factor for renal, cardiovascular, and cerebrovascular diseases. Yet, the underlying mechanisms remain poorly understood. The proposed study determines how renal oxygenation and substrate metabolism differs between individuals with and without salt sensitivity, with the ultimate goal of identifying mechanisms, diagnostic criteria, and treatment strategies for salt sensitive hypertension.
Key Details
Gender
All
Age Range
30 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
70
Start Date
2021-11-01
Completion Date
2030-01-30
Last Updated
2025-11-13
Healthy Volunteers
No
Conditions
Interventions
Low sodium diet
Subjects will be started on a low sodium (food will be provided) for two weeks.
high sodium diet
Subjects will be started on high sodium diet (regular diet supplemented with salt tablets to reach a daily intake of \> 4200 mg/Day) for two weeks.
Locations (1)
Medical College of Wisconsin /Froedtert Hospital
Milwaukee, Wisconsin, United States