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Vonoprazan-Based Triple Therapy in Comparison With Extended Sequential Therapy
Sponsor: Fu Jen Catholic University Hospital
Summary
This study aims to compare the efficacy of the current standard first-line anti-helicobacter pylori regimen, extended proton pump inhibitor-based sequential therapy, with that of vonoprazan-based triple therapy, through a randomized controlled trial.
Official title: Seven-Day Vonoprazan-Based Triple Therapy With High-Dose Amoxicillin as First-Line Helicobacter Pylori Treatment in Comparison With Extended Sequential Therapy: A Randomized Controlled Trial in Taiwan
Key Details
Gender
All
Age Range
20 Years - Any
Study Type
INTERVENTIONAL
Enrollment
628
Start Date
2021-12-01
Completion Date
2024-02-28
Last Updated
2026-07-17
Healthy Volunteers
No
Conditions
Interventions
Vonoprazan-based triple therapy
vonoprazan 20mg+amoxicillin 1000 mg + clarithromycin 500 mg twice daily for seven days
Extended sequential therapy
Lansoprazole 30mg + amoxicillin 1000mg twice daily for 7 days, followed by lansoprazole 30mg + clarithromycin 500mg + metronidazole 500mg twice daily for 7 days
Locations (1)
Fu Jen Catholic University Hospital
New Taipei City, Taiwan