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Long-term COVID and Rehabilitation
Sponsor: VA Office of Research and Development
Summary
The proposed focuses on improving both morbidity and mortality in older Veterans and those recovering from COVID-19 by developing rehabilitation therapies to augment vascular endothelial function by combating the oxidative stress and inflammation associated with aging and further induced by COVID-19. The investigators expected outcomes will have an important positive impact because they will provide scientifically sound recommendations for rehabilitation to improve vascular endothelial function and minimize the long-term consequences of COVID-19.
Official title: Evaluating the Long-term Health Consequences of COVID-19 and Rehabilitation Therapies to Speed Convalescence
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
300
Start Date
2022-11-01
Completion Date
2028-10-31
Last Updated
2025-09-18
Healthy Volunteers
Yes
Conditions
Interventions
Mitoquinone
Mito-Q is a supplement that targets mitochondrial function. Linking a triphenyl-phosphonium cation to coenzyme-Q, to produce Mito-Q, results in a lipophilic compound, which, due to the large mitochondrial membrane potential, selectively accumulates within mitochondria. This targeted antioxidant approach results in 50- to 100-fold more Mito-Q accumulation compared to non-targeted antioxidant delivery.
Placebo
A placebo will be used in combination with exercise rehabilitation allowing for a double blinded placebo controlled design.
Locations (1)
VA Salt Lake City Health Care System, Salt Lake City, UT
Salt Lake City, Utah, United States