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Identification of Hepatic Fibrosis Using 4D-MRI
Sponsor: University Hospital, Basel, Switzerland
Summary
To date, no specific treatment options exist for liver diseases, and there is a large global effort to find drugs that will halt liver disease progression in these patients.Liver fibrosis staging is essential as a diagnostic/prognostic measure and there is an increasing demand for accurate non-invasive liver stiffness measurement tools. This research project proposes a novel MR-based quantitative Liver Deformation Biomarker (qLDB) approach for non-invasive liver fibrosis assessment by using a new technique called 4D-MRI. 4D-MRI allows to overcome the limitations of currently used techniques. Hence, 4D-MRI may help to identify a novel biomarker for non-invasive staging of liver fibrosis , and therefore improve the final diagnosis of patients suffering from liver diseases.
Official title: Noninvasive Stage Identification of Hepatic Fibrosis Using 4D-MRI
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2021-08-01
Completion Date
2026-12-31
Last Updated
2025-03-18
Healthy Volunteers
Yes
Conditions
Interventions
4D-MRI
Novel MR-imaging (MRI) and postprocessing techniques, making it possible to capture breathing-induced abdominal motion, including liver motion, under free-breathing. For the first time, these techniques - called 4D-MRI - were able to capture the abdominal organs with high spatial resolution in 3-dimensions at a high frame rate of 2-3 Hz and enabled an entirely new insight into the human body.
Locations (2)
Kantonsspital Baselland (KSL)
Liestal, Basel-Landschaft, Switzerland
University Hospital Basel
Basel, Canton of Basel-City, Switzerland