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UNICORNS: Uveitis in Childhood Prospective National Cohort Study
Sponsor: Institute of Child Health
Summary
Childhood uveitis (inflammation inside the eye) is an uncommon disorder that carries the risk of blindness. Inadequate treatment of active inflammation has been shown to be related to a poor outcome. There has been no population-based, prospective longitudinal study of all-cause childhood uveitis, with resultant limitations in the evidence base used to counsel affected families, balance treatment decisions, or plan further research. The aim of the study is to describe the characteristics of childhood-onset uveitis and describe outcomes. The investigators shall also aim to identify the socio-demographic, clinical, biological and treatment-related determinants of outcome. Early (1-2 years following diagnosis) outcomes will be described in the first instance: However, through the creation of a national inception cohort, the investigators shall enable longer-term studies of outcome for affected children and families. There will be no change to routine clinical care.
Official title: Uveitis in Childhood Prospective National Cohort Study
Key Details
Gender
All
Age Range
Any - 18 Years
Study Type
OBSERVATIONAL
Enrollment
250
Start Date
2020-10-22
Completion Date
2026-12
Last Updated
2024-10-04
Healthy Volunteers
No
Conditions
Locations (31)
Belfast Royal Victoria Hospital NHS Foundation Trust
Belfast, United Kingdom
Birmingham Women's and Children's Hospital NHS Foundation Trust
Birmingham, United Kingdom
Royal Bournemouth Christchurch Hospitals NHS Foundation Trust
Bournemouth, United Kingdom
Bradford Teaching Hospitals NHS Foundation Trust
Bradford, United Kingdom
University Hospitals Bristol NHS Foundation Trust
Bristol, United Kingdom
Cambridge University Hospital NHS Foundation Trust
Cambridge, United Kingdom
Cardiff and Vale University Health Board Hospitals
Cardiff, United Kingdom
Mid Essex Hospital Trust
Chelmsford, United Kingdom
Ninewells Hospital
Dundee, United Kingdom
Princess Alexandra Eye Pavilion
Edinburgh, United Kingdom
Royal Children's Hospital
Glasgow, United Kingdom
James Paget University Hospitals NHS Foundation Trust
Great Yarmouth, United Kingdom
Hull University Teaching Hospitals NHS Trust
Hull, United Kingdom
Leeds Teaching Hospitals NHS Trust
Leeds, United Kingdom
Alder Hey Hospital NHS Foundation Trust
Liverpool, United Kingdom
Moorfields Eye Hospital NHS Foundation Trust
London, United Kingdom
Royal Free London NHS Foundation Trust
London, United Kingdom
St Thomas' Hospital
London, United Kingdom
Great Ormond Street Hospital NHS Foundation Trust
London, United Kingdom
Maidstone and Tunbridge Wells NHS Trust
Maidstone, United Kingdom
Manchester University NHS Foundation Trust
Manchester, United Kingdom
Newcastle Upon Tyne Hospitals NHS Foundation Trust
Newcastle, United Kingdom
Norfolk and Norwich University Hospitals NHS Foundation Trust
Norwich, United Kingdom
Nottingham University Hospitals NHS Trust
Nottingham, United Kingdom
Oxford University Hospitals NHS Foundation Trust
Oxford, United Kingdom
Sussex Eye Hospital and Royal Alexandra Children's Hospital
Redhill, United Kingdom
Sheffield Children's Hospitals NHS Foundation Trust
Sheffield, United Kingdom
University Hospital Southampton NHS Foundation Trust
Southampton, United Kingdom
Southend University Hospital NHS Foundation Trust
Westcliff-on-Sea, United Kingdom
Royal London Hospital
Whitechapel, United Kingdom
York Teaching Hospital NHS Foundation Trust
York, United Kingdom