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Adaptive Optics Retinal Imaging in Inherited and Acquired Retinal Disorders
Sponsor: The Hospital for Sick Children
Summary
This is a Prospective Observational study. The aim of the study is to understand the underlying photoreceptor, retinal pigment epithelium or retinal vascular aberrations in inherited and acquired retinal disorders. The study would use adaptive optics (AO) technology to assist in-vivo visualization of these retinal structures and ascertain changes from normal. Further, by using the AO imaging in patients before and after treatments, this study aims to better understand the effect of various interventions and develop AO as an outcome measure in various retinal disorders.
Official title: Adaptive Optics Imaging in Retinal Disorders
Key Details
Gender
All
Age Range
5 Years - 70 Years
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2022-06-13
Completion Date
2033-06-13
Last Updated
2025-01-10
Healthy Volunteers
Yes
Conditions
Interventions
Adaptive Optics Retinal Camera
The rtx1 is a non-invasive device functions without making contact with the eye. The fundus of the patient's eye is illuminated with the IR light emitted from the illumination optical system. The device is comprised of an optoelectronic sensor (OES) that measures the optical defects, software that calculates the necessary corrections and a deformable mirror (DM) that constantly adapts its shape to restore the image's clarity. The digital camera, which is built into the instrument, receives the images and then the images are recorded in the computer hard disk. The AO image software registers and averages the captured image series in order to reduce noise and produce a final enhanced image. The rtx1 integrates AO technology in a flood illumination imaging system and enables visualizing the retina with a high transverse optical resolution of 250 line-pairs per millimeter.
Locations (1)
The Hospital for Sick Children
Toronto, Ontario, Canada