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Metatranscriptomic Next Generation Sequencing in First Trimester Trophoblast With Increased Fetal Nuchal Translucency (METAHCN)
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
The study is based on the hypothesis that increased nuchal translucency may be associated with a materno fetal infection and that the pathogen responsible for this infection could be identify with metatranscriptomic next-generation sequencing in the trophoblast tissue.
Official title: Pathogen Detection by Metatranscriptomic Next Generation Sequencing in the Trophoblast Collected in Women Carrying a Fetus With Increasing Nuchal Translucency in the First Trimester of Pregnancy
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
110
Start Date
2022-11-07
Completion Date
2026-02
Last Updated
2024-05-03
Healthy Volunteers
No
Interventions
Metatranscriptomic
Analysis with metatranscriptomic next generation sequencing of trophoblast obtained by chorionic villi sampling
Specific microbiologic diagnosis
If a microorganism is detected by metatranscriptomic NGS, specific diagnosis (PCR and serology) will be done in maternal and neonatal samples (blood, urine, saliva)
Locations (1)
Hopital Necker - Enfants malades
Paris, France