Clinical Research Directory
Browse clinical research sites, groups, and studies.
GENOCARE: A Prospective, Randomized Clinical Trial of Genotype-Guided Dosing Versus Usual Care
Sponsor: Reema A. Patel
Summary
This is a prospective, randomized study designed to compare genotype-guided dosing to usual care in patients with pancreas cancer and colorectal cancer who are UGT1A1 intermediate metabolizers (\*1/\*28) (heterozygotes) and usual UGT metabolizers (\*1/\*1). All patients will be assessed for UGT1A1 genotype at screening and those with intermediate or usual UGT1A1 genotypes (\*1/\*28, \*1/\*1) will be randomized to genotype-guided dosing versus usual care.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
178
Start Date
2022-09-28
Completion Date
2027-05
Last Updated
2025-12-16
Healthy Volunteers
No
Conditions
Interventions
Irinotecan
Usual dosing per package insert.
Locations (1)
University of Kentucky
Lexington, Kentucky, United States