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RECRUITING
NCT05391126
NA

GENOCARE: A Prospective, Randomized Clinical Trial of Genotype-Guided Dosing Versus Usual Care

Sponsor: Reema A. Patel

View on ClinicalTrials.gov

Summary

This is a prospective, randomized study designed to compare genotype-guided dosing to usual care in patients with pancreas cancer and colorectal cancer who are UGT1A1 intermediate metabolizers (\*1/\*28) (heterozygotes) and usual UGT metabolizers (\*1/\*1). All patients will be assessed for UGT1A1 genotype at screening and those with intermediate or usual UGT1A1 genotypes (\*1/\*28, \*1/\*1) will be randomized to genotype-guided dosing versus usual care.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

178

Start Date

2022-09-28

Completion Date

2027-05

Last Updated

2025-12-16

Healthy Volunteers

No

Interventions

DRUG

Irinotecan

Usual dosing per package insert.

Locations (1)

University of Kentucky

Lexington, Kentucky, United States