Clinical Research Directory

Inclusion criteria for point-of-care infant HIV testing: 1. Mother 18 years of age or older 2. Mother willing and able to provide verbal consent for infant testing 3. Infant birth weight ≥1.5kg 4. Presence of any of the following risk factors: \<12 weeks of ART prior to delivery (including no ART); Known HIV-1 viremia (above level of detection) for last test performed or at any time \>24 weeks gestation in pregnancy; CD4 cell count known to be \<350 cells/mm3 within the past year; Self-described poor adherence in pregnancy (1 or more complete days of missed ART) Exclusion criteria for point-of-care infant HIV testing: 1\) Medical condition making it unlikely that the infant will survive to 24 months Inclusion criteria for infant longitudinal treatment cohort: 1. Mother 18 years of age or older 2. Mother willing and able to provide written informed consent for study participation for herself and her infant 3. Positive point-of-care HIV screening for infant (HIV DNA PCR pending or completed) 4. Infant eligible for ART treatment in accordance with the Botswana government program 5. Infant birth weight ≥1.5 kg Exclusion criteria for infant longitudinal treatment cohort: 1. Medical condition making it unlikely that the infant will survive to 24 months 2. Infant unable to start treatment-dose ART \< 168 hours of age 3. Infant unable to attend follow-up visits at a BHP study clinic in Gaborone or Francistown