Clinical Research Directory

Inclusion Criteria: * BMI ≤38.5 kg/m2 * Nonsmoker * Female subjects: postmenopausal * Currently enrolled in the Wisconsin Alzheimer's Disease Research Clinical Core Exclusion Criteria: * Diagnosis of mild cognitive impairment or Alzheimer's disease * Uncontrolled hypertension * History or evidence of hepatic disease, hematological disease, or peripheral vascular disease * Severe kidney injury requiring hemodialysis * Cardiovascular disease including: severe congestive heart failure, coronary artery disease, ischemic heart disease (stents, coronary artery bypass grafts) and tachycardia * History of clinically significant ischemic or hemorrhagic stroke, or significant cerebrovascular disease * History of HIV/AIDS * Severe untreated obstructive sleep apnea * History of diabetes with HbA1c greater than 9.5% * Major neurologic disorders other than dementia (e.g., multiple sclerosis, amyotrophic lateral sclerosis, brain surgery, etc.) * Current or recent (\<1 year) major psychiatric condition (Axis I) or addictive disorders * Contraindications to MRI