Clinical Research Directory

Inclusion Criteria: 1. Meets the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, 5th Edition) diagnostic criteria for depressive disorders 2. Age 18-60 years, gender aside, at least 1 guardian to monitor the patient for 2 months 3. Obtain informed consent from patients and guardians, sign informed consent forms, and be able to comply with planned visits, laboratory tests, and other research procedures 4. It is expected that there will be no problems such as relocation of residence, inconvenience of transportation, and difficulty in obtaining medical treatment throughout the study process 5. There is sufficient audiovisual level to complete the necessary examinations for the study Exclusion Criteria: 1. Presence of any other medical disorder affecting reproductive endocrine function; Abusers of psychoactive substances or substances such as alcohol 2. People with severe physical disabilities who are unable to complete follow-up 3. Have been diagnosed or have had other severe psychiatric disorders that meet the diagnostic criteria for DSM-5, mental retardation, dementia, severe cognitive dysfunction, etc 4. Previously or currently suffering from any major physical disease, neurological disorder, brain trauma, etc. that affect the structure or function of the brain 5. Suicidal or uncooperative 6. Pregnant or lactating women 7. There is significant anxiety, HAMA ≥ 21 points