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A Study Evaluating Rocatinlimab in Moderate-to-severe Atopic Dermatitis (ROCKET-IGNITE)
Sponsor: Amgen
Summary
The purpose of this study is to evaluate the efficacy and safety of rocatinlimab in monotherapy treatment.
Official title: A Phase 3, 24-week, Randomized, Placebo-controlled, Double-blind Study to Assess the Efficacy, Safety and Tolerability of Rocatinlimab (AMG 451) Monotherapy in Adult Subjects With Moderate-to-severe Atopic Dermatitis (AD)
Key Details
Gender
All
Age Range
18 Years - 100 Years
Study Type
INTERVENTIONAL
Enrollment
769
Start Date
2022-05-31
Completion Date
2025-01-13
Last Updated
2026-07-23
Healthy Volunteers
No
Conditions
Interventions
Rocatinlimab
Participants will receive Rocatinlimab subcutaneously.
Placebo
Participants will receive a placebo subcutaneously.
Locations (202)
Cahaba Dermatology and Skin Health Center
Birmingham, Alabama, United States
Alliance Dermatology and Mohs Center
Phoenix, Arizona, United States
Anaheim Clinical Trials
Anaheim, California, United States
First OC Dermatology
Fountain Valley, California, United States
Kaiser Permanente - Glendale Medical Center
Glendale, California, United States
Long Beach Research Institute
Long Beach, California, United States
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, United States
Dermatology Research Associates
Los Angeles, California, United States
Cura Clinical Research
Sherman Oaks, California, United States
IMMUNOe Research Centers
Centennial, Colorado, United States
Skin Care Research Incorporated
Boca Raton, Florida, United States
Palm Beach Dermatology Group
Delray Beach, Florida, United States
Global Research Associates
Homestead, Florida, United States
Healthy Life Research
Miami, Florida, United States
Savin Medical Group LLC
Miami Lakes, Florida, United States
Kirsch Dermatology LLC
Naples, Florida, United States
Pure Skin Dermatology and Aesthetics
Orlando, Florida, United States
Industrial Medicine Associates Ima Clinical Research Inc
St. Petersburg, Florida, United States
Genesis Clinical Research LLC
Tampa, Florida, United States
Treasure Valley Medical Research
Boise, Idaho, United States
DeNova Research
Chicago, Illinois, United States
Dundee Dermatology
West Dundee, Illinois, United States
The Indiana Clinical Trials Center PC
Plainfield, Indiana, United States
Institute for Asthma and Allergy
Chevy Chase, Maryland, United States
Continental Clinical Solutions, LLC
Towson, Maryland, United States
Henry Ford Health System
Detroit, Michigan, United States
Onyx Clinical Research
Flint, Michigan, United States
Dermatology and Skin Cancer Center of Lees Summit
Lee's Summit, Missouri, United States
Jubilee Clinical Research Inc
Las Vegas, Nevada, United States
Allcutis Research, Llc - Portsmouth
Portsmouth, New Hampshire, United States
Continental Clinical Solutions - Cherry Hill
Cherry Hill, New Jersey, United States
Industrial Medicine Associates Ima Clinical Research Inc
Hartsdale, New York, United States
Sadick Research Group
New York, New York, United States
Dermatology Specialists of Charlotte
Charlotte, North Carolina, United States
Onsite Clinical Solutions
Charlotte, North Carolina, United States
Wilmington Dermatology Center
Wilmington, North Carolina, United States
The Skin Surgery Center for Clinical Research
Winston-Salem, North Carolina, United States
Optima Research
Boardman, Ohio, United States
ClinOhio Research Services
Columbus, Ohio, United States
Unity Clinical Research
Oklahoma City, Oklahoma, United States
Dermatology Research Center of Oklahoma, PLLC
Tulsa, Oklahoma, United States
Essential Medical Research LLC
Tulsa, Oklahoma, United States
Oregon Health and Science University
Portland, Oregon, United States
DermDox Dermatology, LLC
Sugarloaf, Pennsylvania, United States
Cumberland Skin Center
Hermitage, Tennessee, United States
Dermatology Treatment and Research Center PA
Dallas, Texas, United States
The Woodlands Dermatology Associates
The Woodlands, Texas, United States
Education and Research Foundation Inc
Lynchburg, Virginia, United States
Frontier Derm Partners
Mill Creek, Washington, United States
West Virginia Research Institute
Morgantown, West Virginia, United States
Cinme - Centro de Investigaciones Metabolicas
CABA, Buenos Aires, Argentina
Fundacion Respirar
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Hospital Universitario Austral
Derqui, Pilar, Buenos Aires, Argentina
Centro Dermatológico Schejtman
San Miguel, Buenos Aires, Argentina
InAER - Investigaciones en Alergia y Enfermedades Respiratorias
Buenos Aires, Distrito Federal, Argentina
Instituto de Neumonologia y Dermatologia
Buenos Aires, Distrito Federal, Argentina
Conexa Investigacion Clinica SA
CABA, Distrito Federal, Argentina
Fundacion Estudios Clinicos
Rosario, Santa Fe Province, Argentina
Instituto de Diagnostico Abc American British Cowdray
Rosario, Santa Fe Province, Argentina
Hospital de Clinicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil
Hospital Ernesto Dornelles
Porto Alegre, Rio Grande do Sul, Brazil
Upeclin-Pesq Clin FacMed Botucatu
Botucatu, São Paulo, Brazil
Hosp e Maternidade Dr Christovao da Gama
Santo André, São Paulo, Brazil
Fundacao Abc - Centro Univ Fmabc
Santo André, São Paulo, Brazil
Consultoria Medica e Pesquisa Clinica Cmpc
Sorocaba, São Paulo, Brazil
IBPClin Instituto Brasil de Pesquisa Clinica
Rio de Janeiro, Brazil
Alergoalfa Nucleo Diagnostico Tratamento e Pesquisa Clinica em Alergia
São Paulo, Brazil
Alberta Derma Surgery Centre
Edmonton, Alberta, Canada
Vida Clinical Research
Edmonton, Alberta, Canada
CCA Medical Research Corporation
Ajax, Ontario, Canada
SimcoDerm Medical and Surgical Dermatology Centre
Barrie, Ontario, Canada
LEADER Research
Hamilton, Ontario, Canada
DermEdge Research Incorporated
Mississauga, Ontario, Canada
Canadian Dermatology Centre
North York, Ontario, Canada
Gordon Sussman Clinical Research Incorporated
North York, Ontario, Canada
Oak Ridges Aesthetics Centre
Richmond Hill, Ontario, Canada
Innovaderm Research Inc
Montreal, Quebec, Canada
Recherche Clinique Sigma Incorporated
Québec, Quebec, Canada
Skinsense Medical Research
Saskatoon, Saskatchewan, Canada
Beijing Friendship Hospital, Capital Medical University
Beijing, Beijing Municipality, China
Peking University Third Hospital
Beijing, Beijing Municipality, China
The First Affiliated Hospital of Fujian Medical University
Fuzhou, Fujian, China
The First Affiliated Hospital ,Sun-Yat Sen University
Guangzhou, Guangdong, China
Dermatology Hospital of Southern Medical University
Guangzhou, Guangdong, China
Sun Yat-sen Memorial Hospital Sun Yat-sen University
Guangzhou, Guangdong, China
The First Hospital Of Hebei Medical University
Shijiazhuang, Hebei, China
Nanyang First Peoples Hospital
Nanyang, Henan, China
Sanmenxia Central Hospital
Sanmenxia, Henan, China
Union Hospital Tongji Medical College Huazhong University of science and Technology
Wuhan, Hubei, China
The Second Xiangya Hospital of Central South University
Changsha, Hunan, China
Jiangyin Hospital of Traditional Chinese Medicine
Jiangyin, Jiangsu, China
Wuxi Peoples Hospital
Wuxi, Jiangsu, China
Dermatology Hospital of Jiangxi Province
Nanchang, Jiangxi, China
The First Hospital of Jilin University
Changchun, Jilin, China
The First Hospital of China Medical University
Shenyang, Liaoning, China
Chengdu Second Peoples Hospital
Chengdu, Sichuan, China
the First Affiliated Hospital Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
Zhejiang Provincial Peoples Hospital
Hangzhou, Zhejiang, China
Affiliated Hangzhou First Peoples Hospital，Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
Taizhou Central Hospital
Taizhou, Zhejiang, China