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RECRUITING
NCT05400733
NA

Prandial Metabolic Phenotype in Adults

Sponsor: Texas A&M University

View on ClinicalTrials.gov

Summary

Previous studies suggest that changes in metabolism due to the effects of aging might serve as a potential for therapeutic agents. The investigating lab developed a pulse method combining multiple stable isotopes to study multiple metabolic pathways in the same individual simultaneously. By measuring whole-body metabolism in a large group of older adults, the investigators may be able to unravel age-related deterioration in protein turnover (synthesis and breakdown) that contributes to impaired functional capacity. Metabolic profiles could explain differences in pathways in the aging process with special interest in metabolism of amino acids as they have been associated with aging-related disorders.

Key Details

Gender

All

Age Range

60 Years - 80 Years

Study Type

INTERVENTIONAL

Enrollment

50

Start Date

2022-06-24

Completion Date

2026-09

Last Updated

2025-10-01

Healthy Volunteers

Yes

Interventions

DIETARY_SUPPLEMENT

Total Amino Acids

Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine, Alanine, Arginine, Aspartate, Cystine, Glutamine, Glutamate, Glycine, Proline, Serine, Tyrosine. All supplements are commercially available.

DIETARY_SUPPLEMENT

Essential Amino Acids

Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine. All supplements are commercially available.

DIETARY_SUPPLEMENT

Essential Amino Acids + Hydroxy-methylbutyric acid (HMB)

Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine, HMB. All supplements are commercially available.

DIETARY_SUPPLEMENT

Essential Amino Acids + Leucine

Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine, Extra leucine. All supplements are commercially available.

DIETARY_SUPPLEMENT

Essential Amino Acids High

Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine. All supplements are commercially available.

DIETARY_SUPPLEMENT

Placebo Water

Water

Locations (1)

Human Clinical Research Facility

College Station, Texas, United States