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ACTIVE NOT RECRUITING
NCT05402085
NA

N=1 Trials of Individual Variability in Post-prandial Glycemic Responses to Diets of Varying Macronutrient Composition

Sponsor: National University of Singapore

View on ClinicalTrials.gov

Summary

The key objective of this study is to identify the most suitable diet (i.e. high protein, high fat, low GI, high GI) for an individual. Importantly, we further seek to identify the biological determinants of inter-individual variability and to understand how these determinants affect blood glucose. The deep metabolic phenotyping, multi-omics profiling of each subject and fine-mapping of their glycemic responses to different diets will allow us to obtain preliminary data on the mechanistic basis underlying inter-individual dietary glycemic response. Data from this study will form the basis of large clinical trials, the development of novel foods, and/or novel technologies to alter the gut micro-biome for optimal blood glucose control.

Official title: Physiological, Biochemical and Gut Microbial Determinants of Individual Variability in Post-prandial Glycemic Response to Diets of Varying Macronutrient Composition- Towards Personalized Nutrition Through Aggregated N=1 Trials

Key Details

Gender

MALE

Age Range

21 Years - 60 Years

Study Type

INTERVENTIONAL

Enrollment

120

Start Date

2020-09-03

Completion Date

2024-12-31

Last Updated

2024-11-15

Healthy Volunteers

Yes

Interventions

DIETARY_SUPPLEMENT

High Protein Diet

Subjects will be provided with high protein diet meals for breakfast, lunch, and dinner. A continuous glucose monitoring device will be used to measure post-prandial glycemic responses.

DIETARY_SUPPLEMENT

High Fat Diet

Subjects will be provided with high fat diet meals for breakfast, lunch, and dinner. A continuous glucose monitoring device will be used to measure post-prandial glycemic responses.

DIETARY_SUPPLEMENT

High Carbohydrate-Low Glycemic Index Diet

Subjects will be provided with high carbohydrate-low glycemic index diet meals for breakfast, lunch, and dinner. A continuous glucose monitoring device will be used to measure post-prandial glycemic responses.

DIETARY_SUPPLEMENT

High Carbohydrate-High Glycemic Index Diet

Subjects will be provided with high carbohydrate-high glycemic index diet meals for breakfast, lunch, and dinner. A continuous glucose monitoring device will be used to measure post-prandial glycemic responses.

Locations (1)

National University of Singapore

Singapore, Singapore, Singapore