Clinical Research Directory

Inclusion Criteria: * Good general health or confirmed diagnosis of neurodegenerative disease associated with abnormal protein aggregation along international criteria * Age above 18 years * In ambulant setting: ability to apply the ambulant EEG device for the duration of the study, either alone or with help of co-habitant if MoCA \< 20 Exclusion Criteria: * Failure to give informed consent * Inability to follow the procedures of the study, e.g. due to language problems or cognitive deficits * Known or suspected non-compliance, drug- or medication abuse * Inability to hear the tones to be applied during sleep in auditory stimulation experiments * Skin disorders/problems/allergies in face/ear area that could worsen with electrode application * Regular intake of drugs that may alter the relationship between sleep and outcome variables under investigation (opioids, benzodiazepines and z-drugs (nonbenzodiazepines)). * Clinically significant concomitant disease states * Too high (disease) burden for patients * Additional non-medical exclusion criteria may be defined for certain cognitive tasks (e.g. no glasses during experiments involving eye tracking)