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Targeting Nociceptors in Hidradenitis Suppurativa
Sponsor: University of Massachusetts, Worcester
Summary
This study will build on data from mice and humans implicating TRPV1 nociceptors in the pathogenesis of the type-17 chronic inflammatory skin disease Hidradenitis Suppurativa (HS). In this study, the investigators will test the hypothesis that inhibiting neuropeptide activity with botulinum toxin reduces pathogenic inflammation.
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
OBSERVATIONAL
Enrollment
20
Start Date
2022-06-07
Completion Date
2028-04-30
Last Updated
2026-09-10
Healthy Volunteers
No
Conditions
Interventions
Botulinum toxin
Administration of botulinum toxin (50 units/100cm2 injected intradermally) into lesional skin
Locations (1)
University of Massachusetts Chan Medical School
Worcester, Massachusetts, United States