Clinical Research Directory

Inclusion Criteria: * Personally signed and dated written informed consent, * Histological diagnosis of malignancy, * Histologically or radiologically diagnosed bone metastasis, * Age ≥ 18 years * Pain or under pain control medication Exclusion Criteria: * Pregnant or lactating women, * Women of childbearing potential or sexually active males not willing to use effective contraception while on treatment and 3 months after the end of treatment, * Inability to follow the procedures of the study, e.g., due to language problems, psychological disorders, dementia, etc., * Prior radiotherapy to the intended treatment site, * Lesions \> 5cm in maximum diameter, * Prior treatment with radioactive isotopes within 30 days of randomisation, * Spinal column, hands, feet, or head as intended treatment site,- Fracture at the intended treatment site, * Surgery required or previous surgery at the intended treatment site * Instability of the intended treatment site.