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COMPLETED
NCT05407675
PHASE1/PHASE2

A Study to Evaluate the Safety and Tolerability of BMS-986408 Alone and in Combination With Nivolumab or Nivolumab and Ipilimumab in Participants With Advanced Solid Tumors

Sponsor: Bristol-Myers Squibb

View on ClinicalTrials.gov

Summary

The primary purpose of this study is to characterize the safety profile of BMS-986408 as monotherapy and in combination with nivolumab or nivolumab and ipilimumab to establish the maximum tolerated dose (MTD). The Recommended Phase 2 Dose (RP2D) that optimizes the pharmacokinetic/pharmacodynamic (PK/PD) relationship of BMS-986408 will also be determined.

Official title: A Phase 1/2 Study of BMS-986408 Alone and in Combination With Nivolumab or With Nivolumab and Ipilimumab in Participants With Advanced Solid Tumors

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

68

Start Date

2022-08-02

Completion Date

2025-07-24

Last Updated

2026-08-13

Healthy Volunteers

No

Interventions

DRUG

BMS-986408

Specified dose on specified days

BIOLOGICAL

Nivolumab

Specified dose on specified days

BIOLOGICAL

Ipilimumab

Specified dose on specified days

BIOLOGICAL

Platinum-doublet chemotherapy

Specified dose on specified days

DRUG

Rabeprazole

Specified dose on specified days

Locations (18)

Local Institution - 0010

Boston, Massachusetts, United States

Local Institution - 0001

Hackensack, New Jersey, United States

Local Institution - 0003

Houston, Texas, United States

Local Institution - 0007

Edmonton, Alberta, Canada

Local Institution - 0011

Hamilton, Ontario, Canada

Local Institution - 0005

Ottawa, Ontario, Canada

Local Institution - 0006

Toronto, Ontario, Canada

Local Institution - 0015

Bordeaux, Aquitaine, France

Local Institution - 0014

Villejuif, Paris, France

Local Institution - 0018

Marseille, France

Local Institution - 0019

Toulouse, France

Local Institution - 0024

Málaga, Andalusia, Spain

Local Institution - 0022

Madrid, Madrid, Spain

Local Institution - 0023

Madrid, Madrid, Spain

Local Institution - 0025

Madrid, Madrid, Comunidad de, Spain

Local Institution - 0021

Sankt Gallen, Canton of St. Gallen, Switzerland

Local Institution - 0012

Basel, Switzerland

Local Institution - 0020

Geneva, Switzerland