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A Study to Evaluate the Safety and Tolerability of BMS-986408 Alone and in Combination With Nivolumab or Nivolumab and Ipilimumab in Participants With Advanced Solid Tumors
Sponsor: Bristol-Myers Squibb
Summary
The primary purpose of this study is to characterize the safety profile of BMS-986408 as monotherapy and in combination with nivolumab or nivolumab and ipilimumab to establish the maximum tolerated dose (MTD). The Recommended Phase 2 Dose (RP2D) that optimizes the pharmacokinetic/pharmacodynamic (PK/PD) relationship of BMS-986408 will also be determined.
Official title: A Phase 1/2 Study of BMS-986408 Alone and in Combination With Nivolumab or With Nivolumab and Ipilimumab in Participants With Advanced Solid Tumors
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
68
Start Date
2022-08-02
Completion Date
2025-07-24
Last Updated
2026-08-13
Healthy Volunteers
No
Conditions
Interventions
BMS-986408
Specified dose on specified days
Nivolumab
Specified dose on specified days
Ipilimumab
Specified dose on specified days
Platinum-doublet chemotherapy
Specified dose on specified days
Rabeprazole
Specified dose on specified days
Locations (18)
Local Institution - 0010
Boston, Massachusetts, United States
Local Institution - 0001
Hackensack, New Jersey, United States
Local Institution - 0003
Houston, Texas, United States
Local Institution - 0007
Edmonton, Alberta, Canada
Local Institution - 0011
Hamilton, Ontario, Canada
Local Institution - 0005
Ottawa, Ontario, Canada
Local Institution - 0006
Toronto, Ontario, Canada
Local Institution - 0015
Bordeaux, Aquitaine, France
Local Institution - 0014
Villejuif, Paris, France
Local Institution - 0018
Marseille, France
Local Institution - 0019
Toulouse, France
Local Institution - 0024
Málaga, Andalusia, Spain
Local Institution - 0022
Madrid, Madrid, Spain
Local Institution - 0023
Madrid, Madrid, Spain
Local Institution - 0025
Madrid, Madrid, Comunidad de, Spain
Local Institution - 0021
Sankt Gallen, Canton of St. Gallen, Switzerland
Local Institution - 0012
Basel, Switzerland
Local Institution - 0020
Geneva, Switzerland