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Prevention of Age-associated Cardiac and Vascular Dysfunction Using Avmacol ES
Sponsor: Texas Tech University Health Sciences Center
Summary
Our local IRB approved clinical studies seeking proof of principle for the hypothesis that SFN can be safely administered to humans at doses sufficient to protect age-associated cardiac dysfunctions. Beneficial effects of SFN-therapy will be assessed by Pre- and post-intervention echocardiography, and exercise endurance at 0 and 24 weeks. Peripheral blood cells from treated and control subjects will be compared for mitochondrial respiratory function, oxidative damage, pro-inflammatory cytokines, and expression of antioxidant \& anti-electrophile genes.
Official title: Prevention of Age-associated Cardiac and Vascular Dysfunction Through Nrf2 Signaling Using the Nutritional Supplement Sulforaphane
Key Details
Gender
All
Age Range
60 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2022-07-01
Completion Date
2026-07-30
Last Updated
2024-11-06
Healthy Volunteers
Yes
Interventions
Sulforaphane
Caplets containing SFN-rich broccoli sprout extracts or placebo caplets containing microcrystalline cellulose will be obtained from from Nutramax Labs.
Locations (1)
Texas Tech University Health Sciences Center (TTUHSC)
Lubbock, Texas, United States