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Dietary Sugar Absorptive Phenotype for Prediction of Weight Loss Outcome
Sponsor: Mayo Clinic
Summary
This study is trying to determine whether the success of bariatric surgery can be predicted by evaluating the dietary sugar absorptive characteristics in the small intestine and if there is any gene expression change on the dietary sugar absorptive characteristics.
Official title: Dietary Sugar Hyper-absorptive Intestinal Phenotype as a Predictor of Weight Loss Post-bariatric Surgery
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
52
Start Date
2022-07-10
Completion Date
2026-08
Last Updated
2025-09-10
Healthy Volunteers
Yes
Conditions
Interventions
Endoscopic biopsy
Upper small intestinal biopsies from patients undergoing BS will be collected during routine standard of care screening EGD and again from the same patients at 1 year during routine standard of care surveillance EGD (esophageal reflux screening/surveillance). Biopsy-derived enteroid cultures and tissue samples from pre- and one-year post BS will be examined for expression level of sugar transporters and gluconeogenic enzymes; glucose and fructose absorption
Locations (1)
Mayo Clinic Florida
Jacksonville, Florida, United States