Clinical Research Directory

Inclusion Criteria: * Patients aged between 18 and 80 * Patients suspected for high-risk GIST by preoperative imaging examinations or diagnosed with high-risk GIST by pathological biopsy, who have not received preoperative neoadjuvant treatment * Patients must have not received any treatment including radiotherapy, chemotherapy or surgery * The function of other organs including liver and kidneys is good enough so that the patients could tolerate targeted therapy and surgery * Postoperative pathology conformed the diagnosis of high-risk GIST * Patients and their families could understand the protocol of this study and voluntarily agree to participate in. Signed informed consents are required Exclusion Criteria: * Previous medical history of malignant tumors or synchronous other malignancies * Emergent surgery because of bowel obstruction, perforation or bleeding * Pregnant or lactant women * Medical history of severe mental illness * Patients with contraindication for targeted therapy and surgery * Non-R0 resection * Postoperative pathology conformed the diagnosis of non-high-risk GIST * Patients with distant metastasis * Other situations in which researchers consider that the patient is unsuitable for this study