Clinical Research Directory

Inclusion Criteria: * Subject must be able and willing to provide written informed consent and comply with the requirements of the study protocol; * Subject must be able to read and understand English; * Any gender and any Fitzpatrick skin type; * Age equal to or greater than 18 years old; * Willing to sun protect treated area (sunscreen or cover the area with clothes) for the duration of enrollment in the study and 1 year after treatment. * Subjects must be willing to undergo skin biopsies Exclusion Criteria: * Participation in another investigational drug or device clinical trial in the past 30 days; * Are pregnant or lactating; * History of allergic reaction to topical or local anesthesia; * History of allergic reaction to Doxycycline or other tetracyclines; * Regular intake of high doses of anti-inflammatory drugs (aspirin \>81 mg/day, ibuprofen, corticosteroids, etc.) , immunosuppressive drugs or biologics; * Clinically significant abnormal findings or conditions which might, in the opinion of the Investigator, interfere with study evaluations or pose a risk to subject safety during the study; * Laser treatment in past six months; History of poor wound healing; * History of keloids; History of extreme photosensitivity; * History of severe hyperpigmentation; History of tattoos on thighs.