Clinical Research Directory
Browse clinical research sites, groups, and studies.
PRP in ACLR to Prevent PTOA
Sponsor: Hospital for Special Surgery, New York
Summary
The purpose of our study is to examine the effect of platelet-rich-plasma (PRP) injection on the short-term resolution of post-injury inflammation (biomarkers) and improvement in joint function in patients with acute ACL injury. This RCT has been powered based on the questionnaire KOOS Jr. but it is considered a 'pilot study' in terms of the lab analysis proposed.
Official title: Platelet Rich Plasma (PRP) Treatment of the Anterior Cruciate Ligament Injured Knee to Decrease the Risk of Post-traumatic Osteoarthritis (PTOA): a Randomized Double-blind Controlled Trial
Key Details
Gender
All
Age Range
14 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
56
Start Date
2022-06-27
Completion Date
2026-12-31
Last Updated
2026-02-13
Healthy Volunteers
No
Interventions
platelet rich plasma (PRP) injection
We aim to evaluate early catabolic and inflammatory changes in knee joints in patients receiving PRP injections following ACL injury, as these patients are at higher risk of developing PTOA. We also aim to establish correlations between markers of biologic activity of PRP and clinical outcomes (including both patient-reported outcomes and clinical functional outcomes), with emphasis on cellular and molecular inflammatory parameters modulated by PRP.
placebo saline injection
Patients randomized into the control arm will receive the placebo or saline injection
Locations (1)
Hospital for Special Surgery
New York, New York, United States