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Effect of CoQ10 on the Endocrine Function of Skeletal Muscle
Sponsor: Medical University of Gdansk
Summary
Recent studies have also shown that repeated episodes of ischemia, followed by reperfusion (IPC), can contribute to the development of adaptive changes not only in the area of the heart muscle, but also in the structure of the skeletal muscles. In the project, several research questions will be evaluated e.g. what is the relationship between oxidative stress parameters, uric acid concentration and nitric oxide degradation products in groups of people undergoing two-week training in ischemic training, or what is the relationship between the expression of genes associated with muscle cell growth (e.g. myostatin gene) and the effect of ischemia preconditioning training etc.
Official title: The Effect of Ischemic Preconditioning and Physical Exercise on the Endocrine Function of Skeletal Muscle - the Effect of CoQ10 Supplementation. In Vivo and in Vitro Studies.
Key Details
Gender
MALE
Age Range
21 Years - 29 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2023-03-01
Completion Date
2026-09-30
Last Updated
2023-01-04
Healthy Volunteers
Yes
Interventions
CoQ10 supplementation
Young men training endurance running will be supplemented with CoQ10
Ischemic preconditioning training
Young men training endurance running will undergo IPC training
IPC training combined with CoQ10 supplementation
Young men training endurance running will undergo IPC training combined with CoQ10 supplementation
Sham IPC combined with placebo
Young men training endurance running will undergo sham IPC training combined with placebo supplementation
Locations (1)
Jedrzej Antosiewicz
Gdansk, Pomeranian Voivodeship, Poland