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Acceptability and Feasibility of Combination Treatment for Cervical Precancer Among South African Women Living With HIV
Sponsor: UNC Lineberger Comprehensive Cancer Center
Summary
The purpose of this study is to explore whether an anti-cancer medication (5-fluorouracil cream) placed in the vagina after a surgical excision procedure is an acceptable and useful form of treatment for cervical precancer among the woman with HIV infection.
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
180
Start Date
2023-03-22
Completion Date
2025-06-30
Last Updated
2026-08-21
Healthy Volunteers
No
Interventions
5 Fluorouracil (5 FU) Cream
Intravaginal topical chemotherapy, 5-fluorouracil cream
Placebo
Intravaginal topical placebo cream
Locations (1)
Clinical HIV Research Unit Temba Lethu Wing Helen Joseph Hospital
Westdene, Johannesburg, South Africa