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COMPLETED
NCT05413811
NA

Acceptability and Feasibility of Combination Treatment for Cervical Precancer Among South African Women Living With HIV

Sponsor: UNC Lineberger Comprehensive Cancer Center

View on ClinicalTrials.gov

Summary

The purpose of this study is to explore whether an anti-cancer medication (5-fluorouracil cream) placed in the vagina after a surgical excision procedure is an acceptable and useful form of treatment for cervical precancer among the woman with HIV infection.

Key Details

Gender

FEMALE

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

180

Start Date

2023-03-22

Completion Date

2025-06-30

Last Updated

2026-08-21

Healthy Volunteers

No

Interventions

DRUG

5 Fluorouracil (5 FU) Cream

Intravaginal topical chemotherapy, 5-fluorouracil cream

DRUG

Placebo

Intravaginal topical placebo cream

Locations (1)

Clinical HIV Research Unit Temba Lethu Wing Helen Joseph Hospital

Westdene, Johannesburg, South Africa