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The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin Action
Sponsor: Heba M. Ismail
Summary
Ovwerweight and obesity prevalence in persons with T1D has increased, which further complicates management and risk for complications. The proposed study is relevant to public health because it helps us understand the role of the gut microbiome in disease pathophysiology in T1D youth with overweight and obesity as well as potential mechanisms to modify disease.
Official title: The Gut Microbiome in Lean and Overweight Youth With Type 1 Diabetes and Novel Mechanism of Action of Metformin
Key Details
Gender
All
Age Range
11 Years - 18 Years
Study Type
INTERVENTIONAL
Enrollment
114
Start Date
2022-09-30
Completion Date
2026-11-02
Last Updated
2025-07-25
Healthy Volunteers
No
Conditions
Interventions
Metformin
Metformin is an oral medication that improves insulin sensitivity.
Locations (1)
Indiana University School of Medicine
Indianapolis, Indiana, United States