Clinical Research Directory

Inclusion Criteria:≥ 6 months of knee pain with walking * ≥ 6/10 on a 0-10 point numerical rating scale * High grade medial compartment cartilage loss ( Kellgren-Lawrence grade 3 or 4) on plain weight bearing X-ray * Exposed subchondral bone at 110 degrees of flexion by ultrasound examination * Easily visible suprapatellar pouch with quads conttraction. Exclusion Criteria * Current intake of NSAIDs or steroids * Current anticoagulation therapy * Inflammatory or post-infectious knee arthritis * Systemic inflammatory conditions * Knee flexion less than 100 degrees * Knee extension less than 165 degrees * Valgus or varus more than 15 degrees * Any knee injection in the precedign 3 months * BMI more than 50 kg/ meter squared * Gross synovial folds on ultrasound.