Clinical Research Directory

Inclusion Criteria: 1. Adult subject (male or female, 18-75 years); 2. Diagnosed with idiopathic craniofacial dystonia for more than 1 year, including at least one of the eye and oromandibular region. Cervical dystonia may be present; 3. Treated with oral drugs or botulinum toxin injections, but with no satisfactory curative effect; 4. Normal cognitive function with MMSE score ≥ 24; 5. Informed consent signed. Exclusion Criteria: 1. Only cervical dystonia, or combined with dystonia in other parts of the body other than the cervical region; 2. Diagnosed with other neuropsychiatric diseases(Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, etc.); 3. History of brain surgery; 4. Severe depression with HRSD score ≥ 35; 5. Contraindications to neurosurgery(cerebral infarction, hydrocephalus, cerebral atrophy, sequelae of cerebrovascular disease, etc); 6. Contraindications to CT or MRI scanning(claustrophobia, etc); 7. pregnant or breastfeeding female, or has positive pregnancy test prior to randomization; 8. Contraindications to general anesthesia (severe arrhythmia, severe anemia, abnormal liver and kidney function, etc.); 9. Expected lifetime \< 12 months; 10. Currently receiving an investigational drug or device; 11. Other circumstances that the investigator considers unsuitable to participate in this study or that may pose a significant risk to the patient (inability to understand or comply with research procedures and follow-up, etc.).