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Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome
Sponsor: Vanderbilt University Medical Center
Summary
The term post-acute COVID-19 syndrome or Long COVID is a disabling syndrome that persists beyond the 3-month convalescence period after COVID-19 infections. This syndrome affects mostly women (\~80%), present with chronic tachycardia and Orthostatic intolerance symptoms without any identifiable cause. In addition, non-specific symptoms such as fatigue, headache, and "brain fog", commonly described in POTS patients are also present in this novel condition, recently named post-COVID-19 tachycardia syndrome, POTS variant. Reduced Vagal activity and unresolved inflammation is post-COVID-19 POTS is hypothesized as the cause of Long COVID
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2022-06-01
Completion Date
2027-06-30
Last Updated
2026-01-20
Healthy Volunteers
Yes
Conditions
Interventions
Levels of inflammatory cytokine ( IL-6) in post-COVID-19 POTS and controls
Inflammatory and immune profile of post-COVID-19 POTS patients. Reduced PNS activity (vagal tone) in relation to persistent inflammation.
Levels of inflammatory cytokine ( IL-6) in controls
Inflammatory and immune profile of healthy controls. Controls are the subjects who recovered from COVID-19 infection with no sequelae.
Effect on inflammation after chronic PNS stimulation
Inflammatory biomarkers after restoring PNS function in post-COVID-19 POTS patients, by chronic transcutaneous vagus nerve stimulation (tVNS) in post COVID-19 POTS patients
Locations (1)
Vanderbilt University Medical Center
Nashville, Tennessee, United States