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RECRUITING
NCT05421416
PHASE2

Loratadine for the Prevention of G-CSF-related Bone Pain

Sponsor: AHS Cancer Control Alberta

View on ClinicalTrials.gov

Summary

The research question for the current study is: Is loratadine more effective than placebo in preventing G-CSF-related bone pain during autologous hematopoetic stem cell transplant in patients with lymphoma or multiple myeloma? The hypothesis is that prophylaxis with loratadine will help prevent or reduce the severity of bone pain in this setting.

Official title: Loratadine for the Prevention of Bone Pain Caused by Granulocyte Colony Stimulating Factor (G-CSF) During Stem Cell Mobilization

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

78

Start Date

2024-11-28

Completion Date

2026-12-01

Last Updated

2026-02-05

Healthy Volunteers

No

Interventions

DRUG

Loratadine

Loratadine is 2nd generation inverse agonist that exerts its effect by targeting H1 histamine receptors.

DRUG

Placebo

Placebo sugar pill

Locations (1)

Cross Cancer Institute

Edmonton, Alberta, Canada