Clinical Research Directory

Inclusion Criteria: * the age is 18-80 years old; * the pathological diagnosis is clear, patients with local recurrence / metastasis of head and neck tumor after operation or external radiotherapy; * the tumor diameter ≤ 5cm, the number of lesions ≤ 3; * there is a suitable puncture path, and the target dose of pre can reach the prescribed dose; * KPS ≥ 70 points, the expected survival time is more than 3 months; * patients have signed a consent form for I-125 seeds implantation therapy; * patients have signed the consent form of knowing emotions to participate in this observational study; Exclusion Criteria: * coagulation dysfunction; * tumor surface rupture, or tumor memory liquefied and necrotic in a large range, with poor expected particle distribution; * severe underlying diseases, resulting in unsafe completion of I-125 seeds implantation therapy, including active infections requiring drug treatment; * mental abnormalities affecting cognitive ability; * poor compliance and inability to complete treatment; * those who were considered unsuitable to participate in this clinical trial;