Clinical Research Directory

Inclusion Criteria: * 18 years old; * Consistent with the diagnosis of acute ischemic stroke; * 24 hours from onset to enrollment; * Informed consent Exclusion Criteria: * Patients who refuse to receive intravenous thrombolysis or intravascular intervention (including intravascular mechanical thrombolysis and arterial thrombolysis); * Stroke patients caused by brain tumor, brain trauma and blood diseases; * Those with a history of stroke and sequelae affecting the outcome assessment, namely, mRS 2 points before the onset of this stroke; * Combined with claudication osteoarthritis rheumatoid arthritis gout arthritis and other limb dysfunction and affect the neurological function examination; * Patients with severe hepatic and renal insufficiency (Note: Hepatic insufficiency refers to ALT or AST values greater than 2 times the upper normal limit; Renal insufficiency refers to blood creatinine value greater than 2 times the normal upper limit); * Suffering from other serious life-threatening diseases with an expected survival time of less than 3 months; * Other diseases that limit neurological function evaluation or affect patient follow-up; * A woman planning to be pregnant or breastfeeding; * Currently participating in other clinical trials; * Refuse to participate in the registration of investigators