Clinical Research Directory

Inclusion Criteria: * 18 to 80 years old * new onset of multiple myeloma * acute kidney injury with eGFR \< 15 ml/min/1.73m2 and need hemodialysis * biopsy-proven cast nephropathy or clinical diagnosis of cast nephropathy based on exclusion of other causes of acute kidney injury including post-renal obstruction, hypercalcaemia, amyloidosis, light-chain deposition disease, contrast media and drug nephropathy * serum light chain \> 500 mg/L Exclusion Criteria: * chronic kidney disease stage 3 to 5 (eGFR\< 60 ml/min/1.73m2 for at least 3 months) * haemodynamics unstability * active bleeding * cardiovascular and cerebrovascular events in the last month * other malignant tumor * conditions not suitable to participate in the study, such as bad compliance