Clinical Research Directory

Inclusion Criteria: 1. Resident population aged 40-69 in Nanjing, China 2. One or more of the following cardiovascular disease risk factors must be present, as follows: 1. Current or recent (within 12 months) smoker 2. Clinical diagnosis of hypertension (\>140/90mmHg) 3. Hypercholesterolaemia (LDL≥4.1mmol/L or total cholesterol\>6.0 mmol/L, including familial hypercholesterolaemia) 4. Diabetes mellitus 5. Rheumatoid arthritis 6. Systemic lupus erythematosus 7. Family history of premature cardiovascular disease (first degree relative with atherosclerotic cardiovascular disease, males, age\<55 years; females, age\<60 years) 8. Chronic kidney disease stage 3 (eGFR 30\~59mL/min/1.73 m2) Exclusion Criteria: 1. Plan to leave Nanjing within 5 years or be unable to complete the follow-up work 2. Refuse to sign informed consent or inability to understand and comply with the program process 3. Known atherosclerotic cardiovascular disease (eg. angina, coronary heart disease, stroke, transient ischemic attack, peripheral vascular disease) 4. Serious chronic kidney disease (eGFR\< 30 ml/min/1.73 m2) 5. Serious liver disease or dysfunction (chronic active hepatitis and cirrhosis, or aspartate aminotransferase (AST) or alanine transaminase (ALT) \> 3 times the upper limit of normal) 6. Prior coronary computed tomography angiography or invasive coronary angiography within the last 5 years 7. Not appropriate to be tested due to birth planning, allergies, acute thyroid storm, etc 8. Current use of statin therapy 9. Patients with diseases that seriously affect the survival period, such as malignant tumors 10. Other conditions at the discretion of the research group